# CADET Literature Base **URL:** https://forum.cadet-web.de/c/cadet-general-information/cadet-literature-base/10.md?page=1 [Latest](https://forum.cadet-web.de/latest.md) · [Categories](https://forum.cadet-web.de/categories.md) · [Tags](https://forum.cadet-web.de/tags.md) **Page:** 2 --- ## [Nikita et al. (2021): Reinforcement learning based optimization of process chromatography for continuous processing of biopharmaceuticals](https://forum.cadet-web.de/t/nikita-et-al-2021-reinforcement-learning-based-optimization-of-process-chromatography-for-continuous-processing-of-biopharmaceuticals/182)
**Author:** [@lieres](https://forum.cadet-web.de/u/lieres)\ **Replies:** 0\ **Last updated:** [September 29, 2020, 6:35pm UTC](https://forum.cadet-web.de/t/nikita-et-al-2021-reinforcement-learning-based-optimization-of-process-chromatography-for-continuous-processing-of-biopharmaceuticals/182 "2020-09-29T18:35:41Z")
Nikita, S.; Tiwari, A.; Sonawat, D.; Kodamana, H. Rathore, A.: Reinforcement learning based optimization of process chromatography for continuous processing of biopharmaceuticals, Chemical Engineering Science 230 (2021):… --- ## [Deulgaonkar et al. (2021): Mechanistic modeling of continuous capture step purification of biosimilar monoclonal antibody therapeutic](https://forum.cadet-web.de/t/deulgaonkar-et-al-2021-mechanistic-modeling-of-continuous-capture-step-purification-of-biosimilar-monoclonal-antibody-therapeutic/386)
**Author:** [@lieres](https://forum.cadet-web.de/u/lieres)\ **Replies:** 0\ **Last updated:** [September 23, 2021, 7:14pm UTC](https://forum.cadet-web.de/t/deulgaonkar-et-al-2021-mechanistic-modeling-of-continuous-capture-step-purification-of-biosimilar-monoclonal-antibody-therapeutic/386 "2021-09-23T19:14:16Z")
Deulgaonkar, P.; Bhambure, R.; Prasad, B.; Mishra, A.; Tiwari, S.; Mody, R.: Mechanistic modeling of continuous capture step purification of biosimilar monoclonal antibody therapeutic, Chemical Technology and Biotechnolo… --- ## [Kimerer et al. (2021): Role of configurational flexibility on the adsorption kinetics of bivalent bispecific antibodies on porous cation exchange resins](https://forum.cadet-web.de/t/kimerer-et-al-2021-role-of-configurational-flexibility-on-the-adsorption-kinetics-of-bivalent-bispecific-antibodies-on-porous-cation-exchange-resins/396)
**Author:** [@lieres](https://forum.cadet-web.de/u/lieres)\ **Replies:** 0\ **Last updated:** [October 4, 2021, 3:38pm UTC](https://forum.cadet-web.de/t/kimerer-et-al-2021-role-of-configurational-flexibility-on-the-adsorption-kinetics-of-bivalent-bispecific-antibodies-on-porous-cation-exchange-resins/396 "2021-10-04T15:38:45Z")
Kimerer, L.; Pabst, T.; Hunter, A.; Carta, G.: Role of configurational flexibility on the adsorption kinetics of bivalent bispecific antibodies on porous cation exchange resins, Journal of Chromatography A 1655 (2021): 4… --- ## [Kumar et al. (2017): Mechanistic Modeling Based PAT Implementation for Ion‐Exchange Process Chromatography of Charge Variants of Monoclonal Antibody Products](https://forum.cadet-web.de/t/kumar-et-al-2017-mechanistic-modeling-based-pat-implementation-for-ion-exchange-process-chromatography-of-charge-variants-of-monoclonal-antibody-products/189)
**Author:** [@s.leweke](https://forum.cadet-web.de/u/s.leweke)\ **Replies:** 0\ **Last updated:** [October 3, 2020, 2:42pm UTC](https://forum.cadet-web.de/t/kumar-et-al-2017-mechanistic-modeling-based-pat-implementation-for-ion-exchange-process-chromatography-of-charge-variants-of-monoclonal-antibody-products/189 "2020-10-03T14:42:45Z")
Kumar, V.; Rathore, A.S.: Mechanistic Modeling Based PAT Implementation for Ion‐Exchange Process Chromatography of Charge Variants of Monoclonal Antibody Products, Biotechnology Journal 12 (2017): 1700286. --- ## [He et al. (2020): Bayesian inference based process design and uncertainty analysis of simulated moving bed chromatographic systems](https://forum.cadet-web.de/t/he-et-al-2020-bayesian-inference-based-process-design-and-uncertainty-analysis-of-simulated-moving-bed-chromatographic-systems/43)
**Author:** [@lieres](https://forum.cadet-web.de/u/lieres)\ **Replies:** 0\ **Last updated:** [June 9, 2020, 9:05am UTC](https://forum.cadet-web.de/t/he-et-al-2020-bayesian-inference-based-process-design-and-uncertainty-analysis-of-simulated-moving-bed-chromatographic-systems/43 "2020-06-09T09:05:57Z")
He, Q.-L.; Zhao, L.: Bayesian inference based process design and uncertainty analysis of simulated moving bed chromatographic systems, Separation and Purification Technology 246 (2020): 116856. --- ## [Kumar et al. (2015): Mechanistic modeling of ion-exchange process chromatography of charge variants of monoclonal antibody products](https://forum.cadet-web.de/t/kumar-et-al-2015-mechanistic-modeling-of-ion-exchange-process-chromatography-of-charge-variants-of-monoclonal-antibody-products/45)
**Author:** [@s.leweke](https://forum.cadet-web.de/u/s.leweke)\ **Replies:** 0\ **Last updated:** [June 9, 2020, 9:14pm UTC](https://forum.cadet-web.de/t/kumar-et-al-2015-mechanistic-modeling-of-ion-exchange-process-chromatography-of-charge-variants-of-monoclonal-antibody-products/45 "2020-06-09T21:14:28Z")
Kumar, V.; Leweke, S.; von Lieres, E.; Rathore, A.: Mechanistic modeling of ion-exchange process chromatography of charge variants of monoclonal antibody products, Journal of Chromatography A 1426 (2015): 140–153. Param… --- ## [Püttmann et al. (2016): Utilizing algorithmic differentiation to efficiently compute chromatograms and parameter sensitivities](https://forum.cadet-web.de/t/puttmann-et-al-2016-utilizing-algorithmic-differentiation-to-efficiently-compute-chromatograms-and-parameter-sensitivities/39)
**Author:** [@s.leweke](https://forum.cadet-web.de/u/s.leweke)\ **Replies:** 0\ **Last updated:** [June 4, 2020, 6:32pm UTC](https://forum.cadet-web.de/t/puttmann-et-al-2016-utilizing-algorithmic-differentiation-to-efficiently-compute-chromatograms-and-parameter-sensitivities/39 "2020-06-04T18:32:04Z")
Püttmann, A.; Schnittert, S.; Leweke, S.; von Lieres, E.: Utilizing algorithmic differentiation to efficiently compute chromatograms and parameter sensitivities, Chemical Engineering Science 139 (2016): 152–162. Detail… --- ## [Hagemann et al. (2020): Modeling hindered diffusion of antibodies in agarose beads considering pore size reduction due to adsorption](https://forum.cadet-web.de/t/hagemann-et-al-2020-modeling-hindered-diffusion-of-antibodies-in-agarose-beads-considering-pore-size-reduction-due-to-adsorption/68)
**Author:** [@lieres](https://forum.cadet-web.de/u/lieres)\ **Replies:** 0\ **Last updated:** [June 18, 2020, 4:21pm UTC](https://forum.cadet-web.de/t/hagemann-et-al-2020-modeling-hindered-diffusion-of-antibodies-in-agarose-beads-considering-pore-size-reduction-due-to-adsorption/68 "2020-06-18T16:21:45Z")
Hagemann, F.; Adametz, P.; Wessling, M.; Thom, V.: Modeling hindered diffusion of antibodies in agarose beads considering pore size reduction due to adsorption, Journal of Chromatography A 1626 (2020): 461319. Model-bas… --- ## [Guo et al. (2020): Optimization of single-column batch and multicolumn continuous protein A chromatography and performance comparison based on mechanistic model](https://forum.cadet-web.de/t/guo-et-al-2020-optimization-of-single-column-batch-and-multicolumn-continuous-protein-a-chromatography-and-performance-comparison-based-on-mechanistic-model/152)
**Author:** [@lieres](https://forum.cadet-web.de/u/lieres)\ **Replies:** 0\ **Last updated:** [August 10, 2020, 9:56am UTC](https://forum.cadet-web.de/t/guo-et-al-2020-optimization-of-single-column-batch-and-multicolumn-continuous-protein-a-chromatography-and-performance-comparison-based-on-mechanistic-model/152 "2020-08-10T09:56:30Z")
Guo, J.; Jin, M.; Kanani, D.: Optimization of single-column batch and multicolumn continuous protein A chromatography and performance comparison based on mechanistic model, Biotechnology Journal 15,10 (2020): 2000192. --- ## [Bernau et al. (2021): Precision analysis for the determination of steric mass action parameters using eight tobacco host cell proteins](https://forum.cadet-web.de/t/bernau-et-al-2021-precision-analysis-for-the-determination-of-steric-mass-action-parameters-using-eight-tobacco-host-cell-proteins/356)
**Author:** [@lieres](https://forum.cadet-web.de/u/lieres)\ **Replies:** 0\ **Last updated:** [July 2, 2021, 5:13pm UTC](https://forum.cadet-web.de/t/bernau-et-al-2021-precision-analysis-for-the-determination-of-steric-mass-action-parameters-using-eight-tobacco-host-cell-proteins/356 "2021-07-02T17:13:36Z")
Bernau, C. R.;.Jäpel, R. C.; Hübbers, J. W.; Nölting, S.; Opdensteinen, P.; Buyel, J. F.: Precision analysis for the determination of steric mass action parameters using eight tobacco host cell proteins, Journal of Chrom… --- ## [Diehm et al. (2023): Development of a 3D printed micro simulated moving bed chromatography system](https://forum.cadet-web.de/t/diehm-et-al-2023-development-of-a-3d-printed-micro-simulated-moving-bed-chromatography-system/658)
**Author:** [@lieres](https://forum.cadet-web.de/u/lieres)\ **Replies:** 0\ **Last updated:** [March 21, 2023, 10:25am UTC](https://forum.cadet-web.de/t/diehm-et-al-2023-development-of-a-3d-printed-micro-simulated-moving-bed-chromatography-system/658 "2023-03-21T10:25:06Z")
Diehm, J.; Ballweg, T.; Franzreb, M.: Development of a 3D printed micro simulated moving bed chromatography system, Journal of Chromatography A 1695 (2023): 463928. CADET applied to account for non-idealities in optimi… --- ## [Breuer et al. (2023): Spatial discontinuous Galerkin spectral element method for a family of chromatography models in CADET](https://forum.cadet-web.de/t/breuer-et-al-2023-spatial-discontinuous-galerkin-spectral-element-method-for-a-family-of-chromatography-models-in-cadet/727)
**Author:** [@lieres](https://forum.cadet-web.de/u/lieres)\ **Replies:** 1\ **Last updated:** [July 8, 2023, 8:18pm UTC](https://forum.cadet-web.de/t/breuer-et-al-2023-spatial-discontinuous-galerkin-spectral-element-method-for-a-family-of-chromatography-models-in-cadet/727 "2023-07-08T20:18:22Z")
Breuer, J.; Leweke, S.; Schmölder, J.; Gassner, G.; von Lieres, E.: Spatial discontinuous Galerkin spectral element method for a family of chromatography models in CADET, Computers & Chemical Engineering 177 (2023): 1083… --- ## [Kumar et al. (2022): Modeling the impact of holdup volume from chromatographic workstations on ion-exchange chromatography](https://forum.cadet-web.de/t/kumar-et-al-2022-modeling-the-impact-of-holdup-volume-from-chromatographic-workstations-on-ion-exchange-chromatography/512)
**Author:** [@vijesh](https://forum.cadet-web.de/u/vijesh)\ **Replies:** 0\ **Last updated:** [July 10, 2022, 6:36am UTC](https://forum.cadet-web.de/t/kumar-et-al-2022-modeling-the-impact-of-holdup-volume-from-chromatographic-workstations-on-ion-exchange-chromatography/512 "2022-07-10T06:36:45Z")
Kumar, V.; Khanal, O. Jin, M.: Modeling the impact of holdup volume from chromatographic workstations on ion-exchange chromatography, Industrial and Engineering Chemistry Research 61,28 (2022): 10195–10204. Another usef… --- ## [Gerstweiler et al. (2022): Control strategy for multi-column continuous periodic counter current chromatography subject to fluctuating inlet stream concentration](https://forum.cadet-web.de/t/gerstweiler-et-al-2022-control-strategy-for-multi-column-continuous-periodic-counter-current-chromatography-subject-to-fluctuating-inlet-stream-concentration/456)
**Author:** [@lieres](https://forum.cadet-web.de/u/lieres)\ **Replies:** 0\ **Last updated:** [February 14, 2022, 6:48pm UTC](https://forum.cadet-web.de/t/gerstweiler-et-al-2022-control-strategy-for-multi-column-continuous-periodic-counter-current-chromatography-subject-to-fluctuating-inlet-stream-concentration/456 "2022-02-14T18:48:01Z")
Gerstweiler, L.; Billakanti, J.; Bi, J.; Middelberg, A.: Control strategy for multi-column continuous periodic counter current chromatography subject to fluctuating inlet stream concentration, Journal of Chromatography A… --- ## [Guo et al. (2022): Effect of solution condition on the binding behaviors of monoclonal antibody and fusion protein therapeutics in Protein A chromatography](https://forum.cadet-web.de/t/guo-et-al-2022-effect-of-solution-condition-on-the-binding-behaviors-of-monoclonal-antibody-and-fusion-protein-therapeutics-in-protein-a-chromatography/624)
**Author:** [@lieres](https://forum.cadet-web.de/u/lieres)\ **Replies:** 0\ **Last updated:** [January 18, 2023, 6:11pm UTC](https://forum.cadet-web.de/t/guo-et-al-2022-effect-of-solution-condition-on-the-binding-behaviors-of-monoclonal-antibody-and-fusion-protein-therapeutics-in-protein-a-chromatography/624 "2023-01-18T18:11:07Z")
Guo, J.; Noyes, S.; Jin, W; Curtis, H.; Xu, X.; Ghose, S.: Effect of solution condition on the binding behaviors of monoclonal antibody and fusion protein therapeutics in Protein A chromatography, Journal of Chromatograp… --- ## [Shekhawat et al. (2022): An accelerated approach for mechanistic model based prediction of linear gradient elution ion-exchange chromatography of proteins](https://forum.cadet-web.de/t/shekhawat-et-al-2022-an-accelerated-approach-for-mechanistic-model-based-prediction-of-linear-gradient-elution-ion-exchange-chromatography-of-proteins/568)
**Author:** [@lieres](https://forum.cadet-web.de/u/lieres)\ **Replies:** 0\ **Last updated:** [October 3, 2022, 7:26pm UTC](https://forum.cadet-web.de/t/shekhawat-et-al-2022-an-accelerated-approach-for-mechanistic-model-based-prediction-of-linear-gradient-elution-ion-exchange-chromatography-of-proteins/568 "2022-10-03T19:26:29Z")
Shekhawat, L.; Tiwari, A.; Yamamoto, S.; Rathorea, A.: An accelerated approach for mechanistic model based prediction of linear gradient elution ion-exchange chromatography of proteins, Journal of Chromatography A 1680 (… --- ## [Jäpel and Buyel (2022): Bayesian optimization using multiple directional objective functions allows the rapid inverse fitting of parameters for chromatography simulations](https://forum.cadet-web.de/t/japel-and-buyel-2022-bayesian-optimization-using-multiple-directional-objective-functions-allows-the-rapid-inverse-fitting-of-parameters-for-chromatography-simulations/534)
**Author:** [@ronald.jaepel](https://forum.cadet-web.de/u/ronald.jaepel)\ **Replies:** 3\ **Last updated:** [August 23, 2022, 4:58am UTC](https://forum.cadet-web.de/t/japel-and-buyel-2022-bayesian-optimization-using-multiple-directional-objective-functions-allows-the-rapid-inverse-fitting-of-parameters-for-chromatography-simulations/534 "2022-08-23T04:58:47Z")
Jäpel, R; Buyel, J: Bayesian optimization using multiple directional objective functions allows the rapid inverse fitting of parameters for chromatography simulations, Journal of Chromatography A 1679 (2022): 463408. Th… --- ## [Yang et al. (2022): Towards next generation high throughput ion exchange membranes for downstream bioprocessing: A review](https://forum.cadet-web.de/t/yang-et-al-2022-towards-next-generation-high-throughput-ion-exchange-membranes-for-downstream-bioprocessing-a-review/453)
**Author:** [@lieres](https://forum.cadet-web.de/u/lieres)\ **Replies:** 0\ **Last updated:** [February 9, 2022, 10:57am UTC](https://forum.cadet-web.de/t/yang-et-al-2022-towards-next-generation-high-throughput-ion-exchange-membranes-for-downstream-bioprocessing-a-review/453 "2022-02-09T10:57:05Z")
Yang, X.; Merenda, A.; Al-Attabi, R.; Dumée, L.; Zhang, X.; Thang, S.; Pham, H.; Kong,L.: Towards next generation high throughput ion exchange membranes for downstream bioprocessing: A review, Journal of Membrane Science… --- ## [Malmström (2022): Orbit-simulator for downstream processes](https://forum.cadet-web.de/t/malmstrom-2022-orbit-simulator-for-downstream-processes/474)
**Author:** [@lieres](https://forum.cadet-web.de/u/lieres)\ **Replies:** 0\ **Last updated:** [April 12, 2022, 8:45am UTC](https://forum.cadet-web.de/t/malmstrom-2022-orbit-simulator-for-downstream-processes/474 "2022-04-12T08:45:23Z")
Malmström, A.: Orbit-simulator for downstream processes, MSc thesis, Lund University, 2022. Control system for ÄKTA systems with potential future integration of CADET. --- ## [Herman et al. (2022): Behavior of weakly adsorbing protein impurities in flow-through ion-exchange chromatography](https://forum.cadet-web.de/t/herman-et-al-2022-behavior-of-weakly-adsorbing-protein-impurities-in-flow-through-ion-exchange-chromatography/447)
**Author:** [@lieres](https://forum.cadet-web.de/u/lieres)\ **Replies:** 0\ **Last updated:** [February 1, 2022, 9:26pm UTC](https://forum.cadet-web.de/t/herman-et-al-2022-behavior-of-weakly-adsorbing-protein-impurities-in-flow-through-ion-exchange-chromatography/447 "2022-02-01T21:26:45Z")
Herman, C.; Xu, X.; Traylor, S.; Ghose, S.; Li, Z.; Lenhoff, A.: Behavior of weakly adsorbing protein impurities in flow-through ion-exchange chromatography, Journal of Chromatography A 1664 (2022): 462788. Includes iso… --- ## [Kumar et al. (2021): Robust mechanistic modeling of protein ion-exchange chromatography using a colloidal isotherm](https://forum.cadet-web.de/t/kumar-et-al-2021-robust-mechanistic-modeling-of-protein-ion-exchange-chromatography-using-a-colloidal-isotherm/409)
**Author:** [@lieres](https://forum.cadet-web.de/u/lieres)\ **Replies:** 2\ **Last updated:** [January 27, 2022, 2:59pm UTC](https://forum.cadet-web.de/t/kumar-et-al-2021-robust-mechanistic-modeling-of-protein-ion-exchange-chromatography-using-a-colloidal-isotherm/409 "2022-01-27T14:59:29Z")
Kumar, V.; Leweke, S.; Heymann, W.; von Lieres, E.; Schlegel, F.; Westerberg, K.; Lenhoff, A.: Robust mechanistic modeling of protein ion-exchange chromatography using a colloidal isotherm, Journal of Chromatography A 16… --- ## [Heymann et al. (2022): Advanced score system and automated search strategies for parameter estimation in mechanistic chromatography modeling](https://forum.cadet-web.de/t/heymann-et-al-2022-advanced-score-system-and-automated-search-strategies-for-parameter-estimation-in-mechanistic-chromatography-modeling/421)
**Author:** [@lieres](https://forum.cadet-web.de/u/lieres)\ **Replies:** 0\ **Last updated:** [November 25, 2021, 7:52am UTC](https://forum.cadet-web.de/t/heymann-et-al-2022-advanced-score-system-and-automated-search-strategies-for-parameter-estimation-in-mechanistic-chromatography-modeling/421 "2021-11-25T07:52:50Z")
Heymann, W.; Glaser, J.; Schlegel, F.; Johnson, W.; Rolandi, P.; von Lieres, E.: Advanced score system and automated search strategies for parameter estimation in mechanistic chromatography modeling, Journal of Chromatog… --- ## [Uche et al. (2021): Investigating the effects of core-shell particles on non-isothermal reactive liquid chromatography](https://forum.cadet-web.de/t/uche-et-al-2021-investigating-the-effects-of-core-shell-particles-on-non-isothermal-reactive-liquid-chromatography/377)
**Author:** [@lieres](https://forum.cadet-web.de/u/lieres)\ **Replies:** 0\ **Last updated:** [September 7, 2021, 2:47pm UTC](https://forum.cadet-web.de/t/uche-et-al-2021-investigating-the-effects-of-core-shell-particles-on-non-isothermal-reactive-liquid-chromatography/377 "2021-09-07T14:47:53Z")
Uche, U.; Uche, M.; Okafor, F.: Investigating the effects of core-shell particles on non-isothermal reactive liquid chromatography, Journal of the Nigerian Mathematical Society 40,2 (2021): 97-128. We should consider im… --- ## [Shekhawat et al. (2020): An overview of mechanistic modeling of liquid chromatography](https://forum.cadet-web.de/t/shekhawat-et-al-2020-an-overview-of-mechanistic-modeling-of-liquid-chromatography/275)
**Author:** [@lieres](https://forum.cadet-web.de/u/lieres)\ **Replies:** 0\ **Last updated:** [December 23, 2020, 8:28am UTC](https://forum.cadet-web.de/t/shekhawat-et-al-2020-an-overview-of-mechanistic-modeling-of-liquid-chromatography/275 "2020-12-23T08:28:39Z")
Shekhawat, L. K.; Rathore, A. S.: An overview of mechanistic modeling of liquid chromatography, Preparative Biochemistry and Biotechnology 49 (2020): 623–638. Review article on mechanistic chromatography modeling. --- ## [Kumar et al. (2020): Mechanistic modeling of preparative column chromatography for biotherapeutics](https://forum.cadet-web.de/t/kumar-et-al-2020-mechanistic-modeling-of-preparative-column-chromatography-for-biotherapeutics/69)
**Author:** [@lieres](https://forum.cadet-web.de/u/lieres)\ **Replies:** 0\ **Last updated:** [June 18, 2020, 4:30pm UTC](https://forum.cadet-web.de/t/kumar-et-al-2020-mechanistic-modeling-of-preparative-column-chromatography-for-biotherapeutics/69 "2020-06-18T16:30:22Z")
Kumar, V.; Lenhoff, A.: Mechanistic modeling of preparative column chromatography for biotherapeutics, Annual Review of Chemical and Biomolecular Engineering 11 (2020): 235–255. Review article on mechanistic chromatogra… [Previous page](https://forum.cadet-web.de/c/cadet-general-information/cadet-literature-base/10.md)