# Latest **URL:** https://forum.cadet-web.de/latest.md [Latest](https://forum.cadet-web.de/latest.md) · [Categories](https://forum.cadet-web.de/categories.md) · [Tags](https://forum.cadet-web.de/tags.md) --- ## [CADET Workshop 2026 Announcement](https://forum.cadet-web.de/t/cadet-workshop-2026-announcement/1429)
**Author:** [@lieres](https://forum.cadet-web.de/u/lieres)\ **Replies:** 0\ **Last updated:** [May 19, 2026, 11:12am UTC](https://forum.cadet-web.de/t/cadet-workshop-2026-announcement/1429 "2026-05-19T11:12:25Z")
Announcement We are happy to announce the seventh CADET tutorial and user workshop on November 4-6, 2026. On the first and second day, we will offer introductory and advanced tutorials for new CADET users. The third day … --- ## [Modeling reverse phase chromatography by CADET](https://forum.cadet-web.de/t/modeling-reverse-phase-chromatography-by-cadet/1329)
**Author:** [@chenkangnan](https://forum.cadet-web.de/u/chenkangnan)\ **Replies:** 13\ **Last updated:** [October 6, 2026, 12:55pm UTC](https://forum.cadet-web.de/t/modeling-reverse-phase-chromatography-by-cadet/1329 "2026-10-06T12:55:46Z")
Hello everyone, Has anyone attempted to model the separation of peptides by reverse phase chromatography using CADET? What model is commonly used in CADET?I have chosen the Mobile Phase Modulator Langmuir (MPM) model, b… --- ## [Chromatography modeling / Introduction Shipeng](https://forum.cadet-web.de/t/chromatography-modeling-introduction-shipeng/1469)
**Author:** [@Shipeng](https://forum.cadet-web.de/u/Shipeng)\ **Replies:** 1\ **Last updated:** [October 6, 2026, 12:54pm UTC](https://forum.cadet-web.de/t/chromatography-modeling-introduction-shipeng/1469 "2026-10-06T12:54:20Z")
Hi everyone, I’m a beginner currently exploring the use of CADET for chromatography process optimization. I hope you can give me some useful learning advice. --- ## [Replicating a six-component IEX case study from Meyer et al. (2026)](https://forum.cadet-web.de/t/replicating-a-six-component-iex-case-study-from-meyer-et-al-2026/1458)
**Author:** [@j.breuer](https://forum.cadet-web.de/u/j.breuer)\ **Replies:** 2\ **Last updated:** [October 6, 2026, 12:17pm UTC](https://forum.cadet-web.de/t/replicating-a-six-component-iex-case-study-from-meyer-et-al-2026/1458 "2026-10-06T12:17:13Z")
Hi everyone, I’ve been setting up the 6-component IEX case study from Meyer et al., 2026, ChromOps.jl (Section 4.2) as I thought it’d be a good standard benchmark for the CADET testing pipelines. ▶ To this end, I mapped … --- ## [Geometry interface decisions before CADET-Core v6.0](https://forum.cadet-web.de/t/geometry-interface-decisions-before-cadet-core-v6-0/1443)
**Author:** [@j.schmoelder](https://forum.cadet-web.de/u/j.schmoelder)\ **Replies:** 8\ **Last updated:** [September 28, 2026, 8:26am UTC](https://forum.cadet-web.de/t/geometry-interface-decisions-before-cadet-core-v6-0/1443 "2026-09-28T08:26:16Z")
This post is about interface choices that should be settled before the CADET-Core v6.0 release. The goal is not to prescribe a full internal rewrite. It is to decide how users and downstream tooling should describe col… --- ## [Issues with running PCC file with CADET-Process on the high power computer cluster (HPC)](https://forum.cadet-web.de/t/issues-with-running-pcc-file-with-cadet-process-on-the-high-power-computer-cluster-hpc/1431)
**Author:** [@Daniella](https://forum.cadet-web.de/u/Daniella)\ **Replies:** 7\ **Last updated:** [August 20, 2026, 2:56pm UTC](https://forum.cadet-web.de/t/issues-with-running-pcc-file-with-cadet-process-on-the-high-power-computer-cluster-hpc/1431 "2026-08-20T14:56:10Z")
I am doing an optimization on my PCC model with the goal of exploring the parameter while doing it. Here is the full PCC process for reference: I have noticed something with the stability of the model on the HPC, ca… --- ## [Using the Lumped Finite Adsorption Rate Model in CADET](https://forum.cadet-web.de/t/using-the-lumped-finite-adsorption-rate-model-in-cadet/1445)
**Author:** [@j.breuer](https://forum.cadet-web.de/u/j.breuer)\ **Replies:** 0\ **Last updated:** [August 5, 2026, 3:17pm UTC](https://forum.cadet-web.de/t/using-the-lumped-finite-adsorption-rate-model-in-cadet/1445 "2026-08-05T15:17:01Z")
This has come up a few times recently, so I thought it’d be useful to write it up here. It’s also exactly the kind of model relationship we’re trying to clarify in the unified and modular modeling framework we’re current… --- ## [CADET-Core v6 pre-releases and release strategy](https://forum.cadet-web.de/t/cadet-core-v6-pre-releases-and-release-strategy/1359)
**Author:** [@j.breuer](https://forum.cadet-web.de/u/j.breuer)\ **Replies:** 4\ **Last updated:** [July 14, 2026, 9:14pm UTC](https://forum.cadet-web.de/t/cadet-core-v6-pre-releases-and-release-strategy/1359 "2026-07-14T21:14:31Z")
Dear CADET users, we would like to inform you about our plan regarding the further development of CADET-Core. Version 6 of CADET-Core is planned and will introduce new features as well as a number of interface changes.… --- ## [CPA Binding Model Implementation in CADET-Core](https://forum.cadet-web.de/t/cpa-binding-model-implementation-in-cadet-core/1422)
**Author:** [@AntoniaBerger](https://forum.cadet-web.de/u/AntoniaBerger)\ **Replies:** 7\ **Last updated:** [July 3, 2026, 6:30am UTC](https://forum.cadet-web.de/t/cpa-binding-model-implementation-in-cadet-core/1422 "2026-07-03T06:30:45Z")
A first prototype of the Colloidal Particle Adsorption (CPA) binding model described by Briskot et al. (2021) has now been implemented in CADET-Core. It is open for testing, and feedback is highly appreciated :blush:. … --- ## [New in CADET-Process: LC Instruments module](https://forum.cadet-web.de/t/new-in-cadet-process-lc-instruments-module/1441)
**Author:** [@j.schmoelder](https://forum.cadet-web.de/u/j.schmoelder)\ **Replies:** 0\ **Last updated:** [June 25, 2026, 1:38pm UTC](https://forum.cadet-web.de/t/new-in-cadet-process-lc-instruments-module/1441 "2026-06-25T13:38:04Z")
We’ve just merged a new instruments module into the dev branch of CADET-Process. It provides ready-made LC system templates and experiment process classes that remove the need to assemble flow sheets and events by hand. … --- ## [The CADET LinkedIn Page Launched!](https://forum.cadet-web.de/t/the-cadet-linkedin-page-launched/1439)
**Author:** [@h.lanzrath](https://forum.cadet-web.de/u/h.lanzrath)\ **Replies:** 0\ **Last updated:** [June 24, 2026, 1:55pm UTC](https://forum.cadet-web.de/t/the-cadet-linkedin-page-launched/1439 "2026-06-24T13:55:28Z")
Follow the CADET LinkedIn Page to stay up-to-date with latest development news and community events! --- ## [Extended Michaelis Menten Model Implementation in CADET-Core](https://forum.cadet-web.de/t/extended-michaelis-menten-model-implementation-in-cadet-core/1434)
**Author:** [@jasovsju](https://forum.cadet-web.de/u/jasovsju)\ **Replies:** 0\ **Last updated:** [June 10, 2026, 1:52pm UTC](https://forum.cadet-web.de/t/extended-michaelis-menten-model-implementation-in-cadet-core/1434 "2026-06-10T13:52:48Z")
Dear CADET Community, an extension of the implemented reaction modul Michaelis-Menten in CADET-Core has been done by including the influence of a non-substrate component (i.e. biomass) in form of a multiplication factor… --- ## [TypeError when using CADET-Match](https://forum.cadet-web.de/t/typeerror-when-using-cadet-match/1401)
**Author:** [@dmeier](https://forum.cadet-web.de/u/dmeier)\ **Replies:** 2\ **Last updated:** [April 20, 2026, 8:34am UTC](https://forum.cadet-web.de/t/typeerror-when-using-cadet-match/1401 "2026-04-20T08:34:08Z")
Dear Cadet Community, since this is my first post in the forum, I want to start by thanking the developers and users alike for creating such a place where vivid exchange about experiences with Cadet is possible. I alrea… --- ## [Examples to use gACT isotherm for (multimodal) cation exchange chromatography with split peaks](https://forum.cadet-web.de/t/examples-to-use-gact-isotherm-for-multimodal-cation-exchange-chromatography-with-split-peaks/1428)
**Author:** [@Flynn](https://forum.cadet-web.de/u/Flynn)\ **Replies:** 1\ **Last updated:** [May 18, 2026, 8:30pm UTC](https://forum.cadet-web.de/t/examples-to-use-gact-isotherm-for-multimodal-cation-exchange-chromatography-with-split-peaks/1428 "2026-05-18T20:30:20Z")
Background As I discussed in the Recovery conference, the design philosophy of ACT isotherm goes far beyond affinity chromatography. In theory, it can be applied to any modes of chromatography as detailed in the paper Ap… --- ## [NIIMBL Request for Proposals (RFP): Data Driven Model for Predicting CADET Model Parameters](https://forum.cadet-web.de/t/niimbl-request-for-proposals-rfp-data-driven-model-for-predicting-cadet-model-parameters/1425)
**Author:** [@rosario.cervellere](https://forum.cadet-web.de/u/rosario.cervellere)\ **Replies:** 1\ **Last updated:** [May 8, 2026, 9:29am UTC](https://forum.cadet-web.de/t/niimbl-request-for-proposals-rfp-data-driven-model-for-predicting-cadet-model-parameters/1425 "2026-05-08T09:29:29Z")
Hello Everyone, I’m the workstream lead for NIIMBL’s BD5 (Big Data) program for downstream process modeling. For FY2027 we’re drafting a request for proposal (RFP) to implement hybrid parameter fitting and process optim… --- ## [CADET-Process v0.12.0](https://forum.cadet-web.de/t/cadet-process-v0-12-0/1424)
**Author:** [@j.schmoelder](https://forum.cadet-web.de/u/j.schmoelder)\ **Replies:** 0\ **Last updated:** [May 5, 2026, 3:33pm UTC](https://forum.cadet-web.de/t/cadet-process-v0-12-0/1424 "2026-05-05T15:33:01Z")
v0.12.0 CADET-Process v0.12.0 is the culmination of 11 months of dedicated development and collaboration. This release introduces significant new features, critical bug fixes, enhanced test coverage, and improved docume… --- ## [Using custom cadet core in Cadet-Process](https://forum.cadet-web.de/t/using-custom-cadet-core-in-cadet-process/1421)
**Author:** [@sasha\_onfleek1](https://forum.cadet-web.de/u/sasha_onfleek1)\ **Replies:** 5\ **Last updated:** [April 15, 2026, 2:45pm UTC](https://forum.cadet-web.de/t/using-custom-cadet-core-in-cadet-process/1421 "2026-04-15T14:45:59Z")
Expected behavior. Hello! Flynn shared with me his version of cadet core that was allowing him to run a two component simulation with the ACT isotherm. Since Im using cadet-process and hes using a more advanced version (… --- ## [Issues possibly related to PyPI metapackage installation (without conda)](https://forum.cadet-web.de/t/issues-possibly-related-to-pypi-metapackage-installation-without-conda/1408)
**Author:** [@ucbevng](https://forum.cadet-web.de/u/ucbevng)\ **Replies:** 10\ **Last updated:** [April 10, 2026, 2:34pm UTC](https://forum.cadet-web.de/t/issues-possibly-related-to-pypi-metapackage-installation-without-conda/1408 "2026-04-10T14:34:41Z")
Expected behavior. Repicating the codes from CADET-Workshop/02 CADET Fundamentals/02.1 first steps/02.1.1\_breakthrough.ipynb at solution · cadet/CADET-Workshop · GitHub Successful autodetection of CADET with “simulator… --- ## [Error when setting recording solid-phase conc in CADET-Process](https://forum.cadet-web.de/t/error-when-setting-recording-solid-phase-conc-in-cadet-process/1347)
**Author:** [@sov\_2024](https://forum.cadet-web.de/u/sov_2024)\ **Replies:** 4\ **Last updated:** [April 9, 2026, 5:35pm UTC](https://forum.cadet-web.de/t/error-when-setting-recording-solid-phase-conc-in-cadet-process/1347 "2026-04-09T17:35:49Z")
Hi, I’m running CADET-Process and trying to get solid-phase concentrations on the resin using the General Rate Model. However, when I set column.solution\_recorder.write\_solution\_solid = False column.solution\_recorder.… --- ## [Accessing/exporting time derivatives from CADET simulations](https://forum.cadet-web.de/t/accessing-exporting-time-derivatives-from-cadet-simulations/1417)
**Author:** [@koko03](https://forum.cadet-web.de/u/koko03)\ **Replies:** 2\ **Last updated:** [March 26, 2026, 10:01am UTC](https://forum.cadet-web.de/t/accessing-exporting-time-derivatives-from-cadet-simulations/1417 "2026-03-26T10:01:03Z")
Hello all, I am currently working with CADET for generating simulation data in the context of physics-informed neural networks (PINNs). I would like to access the time derivatives of the concentration field (dc/dt). My … --- ## [Issues with GIEX fit and two comparators](https://forum.cadet-web.de/t/issues-with-giex-fit-and-two-comparators/1411)
**Author:** [@MoritzImendoerffer](https://forum.cadet-web.de/u/MoritzImendoerffer)\ **Replies:** 2\ **Last updated:** [March 23, 2026, 4:21pm UTC](https://forum.cadet-web.de/t/issues-with-giex-fit-and-two-comparators/1411 "2026-03-23T16:21:54Z")
Expected behavior. I can combine e.g. NRMSE and PeakPosition as metrics for the fit. Actual behavior When using peak position and NRMSE together, I get an error in reduction.py from PyMoo def \_do(self, random\_state=Non… --- ## [Spreading Binding Model - negative concentrations](https://forum.cadet-web.de/t/spreading-binding-model-negative-concentrations/1415)
**Author:** [@ollie\_p](https://forum.cadet-web.de/u/ollie_p)\ **Replies:** 0\ **Last updated:** [March 23, 2026, 4:02pm UTC](https://forum.cadet-web.de/t/spreading-binding-model-negative-concentrations/1415 "2026-03-23T16:02:49Z")
Hello all, I am trying to work with the Multi-Component Spreading Binding model. My end goal is to simulate a process with 3 components (A, B, and C) however I am having issues generating results. In order to trouble-fi… --- ## [Bi-Langmuir q-profiles](https://forum.cadet-web.de/t/bi-langmuir-q-profiles/1406)
**Author:** [@ollie\_p](https://forum.cadet-web.de/u/ollie_p)\ **Replies:** 4\ **Last updated:** [March 23, 2026, 12:47pm UTC](https://forum.cadet-web.de/t/bi-langmuir-q-profiles/1406 "2026-03-23T12:47:19Z")
Hello, I am trying to capture the data on the solid phase concentrations for a case with A and B under various inlet conditions. I can produce plots for outlet concentration but I cannot work out how to get the data of … --- ## [CADET-Core Version 5.1 Release Announcement](https://forum.cadet-web.de/t/cadet-core-version-5-1-release-announcement/1313)
**Author:** [@j.breuer](https://forum.cadet-web.de/u/j.breuer)\ **Replies:** 1\ **Last updated:** [March 18, 2026, 11:04am UTC](https://forum.cadet-web.de/t/cadet-core-version-5-1-release-announcement/1313 "2026-03-18T11:04:47Z")
Announcement The CADET team is happy to announce the release of CADET-Core Version 5.1 ! This minor version release introduces new features and bug fixes. We encourage all users to upgrade to this release to take full a… --- ## [Issue with CSTR Connections and Backflow](https://forum.cadet-web.de/t/issue-with-cstr-connections-and-backflow/1407)
**Author:** [@Anan](https://forum.cadet-web.de/u/Anan)\ **Replies:** 1\ **Last updated:** [March 8, 2026, 5:14pm UTC](https://forum.cadet-web.de/t/issue-with-cstr-connections-and-backflow/1407 "2026-03-08T17:14:30Z")
Dear All, I am encountering a problem with the CSTR connections, where the flow seems to dead-end and backflow occurs to the previous CSTR. I have attached a schematic of the setup for clarity. Here is what I tried: … --- ## [CADET-Core is now on PyPI & we created a metapackage!](https://forum.cadet-web.de/t/cadet-core-is-now-on-pypi-we-created-a-metapackage/1404)
**Author:** [@h.lanzrath](https://forum.cadet-web.de/u/h.lanzrath)\ **Replies:** 0\ **Last updated:** [March 2, 2026, 10:56am UTC](https://forum.cadet-web.de/t/cadet-core-is-now-on-pypi-we-created-a-metapackage/1404 "2026-03-02T10:56:19Z")
We are continuously working to make CADET not only better but also easier to get started with for new users. Concerning this we have two announcements: 1. CADET-Core is now on PyPI We are happy to share that CADET-Core … --- ## [An example to use ACT isotherm for protein A affinity chromatography](https://forum.cadet-web.de/t/an-example-to-use-act-isotherm-for-protein-a-affinity-chromatography/1244)
**Author:** [@Flynn](https://forum.cadet-web.de/u/Flynn)\ **Replies:** 54\ **Last updated:** [February 24, 2026, 9:43am UTC](https://forum.cadet-web.de/t/an-example-to-use-act-isotherm-for-protein-a-affinity-chromatography/1244 "2026-02-24T09:43:55Z")
Introduction The ACT isotherm is a modified Langmuir isotherm tailored for mechanistic modeling in protein A chromatography. It is known that both binding capacity q\_{max} and equilibrium constant (affinity) K\_{eq} chang… --- ## [Dynamic volume flow rate from data](https://forum.cadet-web.de/t/dynamic-volume-flow-rate-from-data/415)
**Author:** [@p.jans](https://forum.cadet-web.de/u/p.jans)\ **Replies:** 7\ **Last updated:** [February 18, 2026, 9:22am UTC](https://forum.cadet-web.de/t/dynamic-volume-flow-rate-from-data/415 "2026-02-18T09:22:01Z")
Hello everyone, Since Cadet version 4.3.0 allows modelling of dynamic flow rates i am trying to implement a dynamic volume flow rate via time step from a dataset. My profil data is stored in a “.csv” file. The first c… --- ## [Congratulations Dr. George Pamenter!](https://forum.cadet-web.de/t/congratulations-dr-george-pamenter/1394)
**Author:** [@lieres](https://forum.cadet-web.de/u/lieres)\ **Replies:** 0\ **Last updated:** [February 16, 2026, 12:16pm UTC](https://forum.cadet-web.de/t/congratulations-dr-george-pamenter/1394 "2026-02-16T12:16:54Z")
Congratulations, George, on successfully defending and publishing your thesis. Cheers to our all-time record holder for CADET Workshop (and social program) appearances in Jülich! --- ## [Cadet Process and Knime?](https://forum.cadet-web.de/t/cadet-process-and-knime/1386)
**Author:** [@MoritzImendoerffer](https://forum.cadet-web.de/u/MoritzImendoerffer)\ **Replies:** 2\ **Last updated:** [February 14, 2026, 1:58pm UTC](https://forum.cadet-web.de/t/cadet-process-and-knime/1386 "2026-02-14T13:58:11Z")
There were at least two attempts to create a GUI for Cadet (at least it seems like so based on the Github Repositories). Since Cadet Process aims at connecting unit operations and Knime does support such connections natu… [Next page](https://forum.cadet-web.de/latest.md?page=1)