# Latest **URL:** https://forum.cadet-web.de/latest.md?page=2 [Latest](https://forum.cadet-web.de/latest.md) · [Categories](https://forum.cadet-web.de/categories.md) · [Tags](https://forum.cadet-web.de/tags.md) **Page:** 3 --- ## [pH dependent isotherm parameter for Langmuir LDF](https://forum.cadet-web.de/t/ph-dependent-isotherm-parameter-for-langmuir-ldf/1210)
**Author:** [@rosario.cervellere](https://forum.cadet-web.de/u/rosario.cervellere)\ **Replies:** 11\ **Last updated:** [August 20, 2025, 8:29pm UTC](https://forum.cadet-web.de/t/ph-dependent-isotherm-parameter-for-langmuir-ldf/1210 "2025-08-20T20:29:39Z")
Hello, I am developing a protein capture model using the lumped rate model without pores and the Langmuir LDF isotherm. I have K\_eq at 5 different pH and want to vary K\_eq based on the local pH with a model fit. The be… --- ## [LRM does not support bulk reactions](https://forum.cadet-web.de/t/lrm-does-not-support-bulk-reactions/1294)
**Author:** [@AN\_IA](https://forum.cadet-web.de/u/AN_IA)\ **Replies:** 2\ **Last updated:** [August 12, 2025, 7:33pm UTC](https://forum.cadet-web.de/t/lrm-does-not-support-bulk-reactions/1294 "2025-08-12T19:33:05Z")
Expected behavior. Hello, I am a bit confused by the behavior I get from CADET when trying to model a bulk reaction in the LRM. Looking at the mathematical model for LRM, I assume I should be able to specify a liquid (b… --- ## [Inquiry About the Future Availability of CPA Model in CADET](https://forum.cadet-web.de/t/inquiry-about-the-future-availability-of-cpa-model-in-cadet/1292)
**Author:** [@LEO](https://forum.cadet-web.de/u/LEO)\ **Replies:** 1\ **Last updated:** [August 11, 2025, 8:56am UTC](https://forum.cadet-web.de/t/inquiry-about-the-future-availability-of-cpa-model-in-cadet/1292 "2025-08-11T08:56:29Z")
I have been extensively utilizing the Colloidal Binding Model in CADET for my tasks. As I continue to explore its capabilities and plan for future work, I am curious about the possibility of incorporating the Colloidal P… --- ## [Enquiry about add\_parameter\_sensitivity](https://forum.cadet-web.de/t/enquiry-about-add-parameter-sensitivity/1290)
**Author:** [@Yang](https://forum.cadet-web.de/u/Yang)\ **Replies:** 6\ **Last updated:** [August 8, 2025, 8:24am UTC](https://forum.cadet-web.de/t/enquiry-about-add-parameter-sensitivity/1290 "2025-08-08T08:24:13Z")
Hello all, I am trying to use the sensitivity analysis feature of cadet-process. Specifically, in my code, I would like to obtain the partial derivative of the concentration at the outlet of tube1 c\_out(L,t) with respec… --- ## [Help debugging GIEX](https://forum.cadet-web.de/t/help-debugging-giex/1284)
**Author:** [@moritz.imend](https://forum.cadet-web.de/u/moritz.imend)\ **Replies:** 1\ **Last updated:** [July 27, 2025, 8:24pm UTC](https://forum.cadet-web.de/t/help-debugging-giex/1284 "2025-07-27T20:24:05Z")
Expected behavior. Hi, I am trying to extend an example from SMA to GIEX using cadet process. I am running it on ubuntu 20.04, with cadet 3.04 (using conda) and Cadet Process as 0.11.1. I would expect the GIEX example t… --- ## [SMA Reference Concentrations](https://forum.cadet-web.de/t/sma-reference-concentrations/1288)
**Author:** [@a.moser](https://forum.cadet-web.de/u/a.moser)\ **Replies:** 0\ **Last updated:** [July 24, 2025, 1:22am UTC](https://forum.cadet-web.de/t/sma-reference-concentrations/1288 "2025-07-24T01:22:30Z")
I wanted to share a note on the SMA isotherm with reference concentrations because I got a bit tripped up with this. I have found using reference concentrations to be helpful because without them I have found some simul… --- ## [Error with DG discretization and EMPM binding model](https://forum.cadet-web.de/t/error-with-dg-discretization-and-empm-binding-model/1283)
**Author:** [@nbarry03](https://forum.cadet-web.de/u/nbarry03)\ **Replies:** 5\ **Last updated:** [July 22, 2025, 2:51pm UTC](https://forum.cadet-web.de/t/error-with-dg-discretization-and-empm-binding-model/1283 "2025-07-22T14:51:49Z")
Expected behavior. Using the DG build of CADET-Core and CADET-Process, SMB built with CarouselBuilder using ExtendedMobilePhaseModulator binding model and DiscontinuousGalerkin discretization runs successfully with float… --- ## [Batch Elution Chromatography Example](https://forum.cadet-web.de/t/batch-elution-chromatography-example/1281)
**Author:** [@sasha\_onfleek1](https://forum.cadet-web.de/u/sasha_onfleek1)\ **Replies:** 4\ **Last updated:** [July 22, 2025, 11:41am UTC](https://forum.cadet-web.de/t/batch-elution-chromatography-example/1281 "2025-07-22T11:41:26Z")
Expected behavior. Heelo! I am new to this and I’m trying to run the first example of CADET Process. I have created an environment (cadet\_env) where I have installed the cadet core and the cadet process (all through cond… --- ## [Colloidal isotherm hangs](https://forum.cadet-web.de/t/colloidal-isotherm-hangs/1273)
**Author:** [@rosario.cervellere](https://forum.cadet-web.de/u/rosario.cervellere)\ **Replies:** 4\ **Last updated:** [July 10, 2025, 6:55am UTC](https://forum.cadet-web.de/t/colloidal-isotherm-hangs/1273 "2025-07-10T06:55:47Z")
Expected behavior. Simulation finishes with no binding. Intent is to fit Bpp and ln(Ke) at individual pH breakthrough and washout, then create pH dependence. Actual behavior Simulation hangs How to produce bug (includi… --- ## [NIIMBL Request for Application (RFA) to Simulate Buffer-Induced pH-Shifts During Chromatography Steps](https://forum.cadet-web.de/t/niimbl-request-for-application-rfa-to-simulate-buffer-induced-ph-shifts-during-chromatography-steps/1272)
**Author:** [@j.schmoelder](https://forum.cadet-web.de/u/j.schmoelder)\ **Replies:** 1\ **Last updated:** [July 7, 2025, 8:23pm UTC](https://forum.cadet-web.de/t/niimbl-request-for-application-rfa-to-simulate-buffer-induced-ph-shifts-during-chromatography-steps/1272 "2025-07-07T20:23:48Z")
We are pleased to announce that NIIMBL has published a Request for Application (RFA) to participate in the Big Data Program initiative to Simulate Buffer-Induced pH-Shifts During Chromatography Steps. Objectives of the … --- ## [Legacy Getting started CADET Introduction](https://forum.cadet-web.de/t/legacy-getting-started-cadet-introduction/1269)
**Author:** [@ysong22](https://forum.cadet-web.de/u/ysong22)\ **Replies:** 2\ **Last updated:** [July 7, 2025, 11:57am UTC](https://forum.cadet-web.de/t/legacy-getting-started-cadet-introduction/1269 "2025-07-07T11:57:46Z")
Hello, I noticed that CADET Introduction is only available as early as V4.3.0. (Getting started — CADET) Any idea how I can find CADET Introduction to older versions such as V4.0.1 Thanks. --- ## [Research Fellow Position: Mechanistic chromatography modeling with CADET and CFD (Australia)](https://forum.cadet-web.de/t/research-fellow-position-mechanistic-chromatography-modeling-with-cadet-and-cfd-australia/1270)
**Author:** [@sandraek](https://forum.cadet-web.de/u/sandraek)\ **Replies:** 0\ **Last updated:** [July 7, 2025, 6:10am UTC](https://forum.cadet-web.de/t/research-fellow-position-mechanistic-chromatography-modeling-with-cadet-and-cfd-australia/1270 "2025-07-07T06:10:42Z")
I am looking for someone with strong skills in mathematical modelling to join my group in a collaborative project with CSL (http://www.csl.com/). The successful candidate will develop mechanistic models of chromatography… --- ## [Leweke et al. (2025): CADET-Core 5.0: High-Performance Solver for Advanced Biotechnology Process Modeling](https://forum.cadet-web.de/t/leweke-et-al-2025-cadet-core-5-0-high-performance-solver-for-advanced-biotechnology-process-modeling/1267)
**Author:** [@lieres](https://forum.cadet-web.de/u/lieres)\ **Replies:** 0\ **Last updated:** [July 3, 2025, 7:47pm UTC](https://forum.cadet-web.de/t/leweke-et-al-2025-cadet-core-5-0-high-performance-solver-for-advanced-biotechnology-process-modeling/1267 "2025-07-03T19:47:36Z")
Leweke, S.; Breuer, J.; Schmölder, J.; Jäpel, R.; Lanzrath, H.; Rao, J.; Hassan, J.; Zhang, W.; Berger, A.; Heymann, W.; von Lieres, E.: CADET-Core 5.0: High-Performance Solver for Advanced Biotechnology Process Modeling,… --- ## [Congratulations Dr. Jesper Frandsen!](https://forum.cadet-web.de/t/congratulations-dr-jesper-frandsen/1265)
**Author:** [@lieres](https://forum.cadet-web.de/u/lieres)\ **Replies:** 0\ **Last updated:** [July 3, 2025, 12:42pm UTC](https://forum.cadet-web.de/t/congratulations-dr-jesper-frandsen/1265 "2025-07-03T12:42:53Z")
Congratulations on the successful defense of your PhD thesis, Jesper! Your work on CADET-Julia has been impressive, not only in terms of technical achievement but also in the way it expands the reach and usability of th… --- ## [How to test experimental features and bug fixes in CADET-Process](https://forum.cadet-web.de/t/how-to-test-experimental-features-and-bug-fixes-in-cadet-process/1254)
**Author:** [@j.schmoelder](https://forum.cadet-web.de/u/j.schmoelder)\ **Replies:** 0\ **Last updated:** [June 27, 2025, 1:22pm UTC](https://forum.cadet-web.de/t/how-to-test-experimental-features-and-bug-fixes-in-cadet-process/1254 "2025-06-27T13:22:42Z")
We frequently receive requests to add new features to CADET-Process or to fix bugs, and we are very grateful to everyone who contacts us and helps us improve our software. This post aims to provide guidance for those les… --- ## [CADET Solution trying to return an array with two differently sized axises](https://forum.cadet-web.de/t/cadet-solution-trying-to-return-an-array-with-two-differently-sized-axises/1253)
**Author:** [@Daniella](https://forum.cadet-web.de/u/Daniella)\ **Replies:** 1\ **Last updated:** [June 27, 2025, 7:35am UTC](https://forum.cadet-web.de/t/cadet-solution-trying-to-return-an-array-with-two-differently-sized-axises/1253 "2025-06-27T07:35:47Z")
Expected behavior. I am trying to add a cstr into my periodic counter current chromatogram code to mimic the flow restrictor on the AKTA. I have a separate code to model a tracer run I did with the CSTR and that works fi… --- ## [Modeling ProtA elution](https://forum.cadet-web.de/t/modeling-prota-elution/1241)
**Author:** [@kautharmaalim](https://forum.cadet-web.de/u/kautharmaalim)\ **Replies:** 3\ **Last updated:** [June 26, 2025, 7:23am UTC](https://forum.cadet-web.de/t/modeling-prota-elution/1241 "2025-06-26T07:23:57Z")
Hi, I was working on modelling elution for the protein A chromatography using Cadet Python. But, what I realised is that it will generate a general outlet concentration because I have not specified the pH and salt condi… --- ## [write\_solution\_solid error with Spreading binding model](https://forum.cadet-web.de/t/write-solution-solid-error-with-spreading-binding-model/1251)
**Author:** [@elenabull](https://forum.cadet-web.de/u/elenabull)\ **Replies:** 1\ **Last updated:** [June 25, 2025, 3:56pm UTC](https://forum.cadet-web.de/t/write-solution-solid-error-with-spreading-binding-model/1251 "2025-06-25T15:56:10Z")
Expected behavior. I’m using the Spreading binding model in CADET-Process (version 0.11.1) and would like to output the solid-phase concentrations of the bound protein in orientation 1 (q1), in orientation 2 (q2), and th… --- ## [Learning materials for studying CADET](https://forum.cadet-web.de/t/learning-materials-for-studying-cadet/1247)
**Author:** [@Kei](https://forum.cadet-web.de/u/Kei)\ **Replies:** 5\ **Last updated:** [June 23, 2025, 1:55pm UTC](https://forum.cadet-web.de/t/learning-materials-for-studying-cadet/1247 "2025-06-23T13:55:40Z")
Thank you for welcoming me to the CADET community! I work at a biopharmaceutical company and am about to start working on chromatography using CADET. I have no prior knowledge in this field, so I would be very grateful … --- ## [negative elution with Langmuir MPM](https://forum.cadet-web.de/t/negative-elution-with-langmuir-mpm/1235)
**Author:** [@rosario.cervellere](https://forum.cadet-web.de/u/rosario.cervellere)\ **Replies:** 5\ **Last updated:** [June 23, 2025, 3:44am UTC](https://forum.cadet-web.de/t/negative-elution-with-langmuir-mpm/1235 "2025-06-23T03:44:20Z")
Expected behavior. Fit Langmuir MPM parameters (offline) to match desired pH dependence. Use fit params to simulate bind, wash, and elute. Actual behavior With certain combinations of MPM params (Ka, gamma, beta) , no b… --- ## [Zhang et al. (2025): An Affinity Complex Titration Isotherm for Mechanistic Modeling in Protein A Chromatography](https://forum.cadet-web.de/t/zhang-et-al-2025-an-affinity-complex-titration-isotherm-for-mechanistic-modeling-in-protein-a-chromatography/1245)
**Author:** [@Flynn](https://forum.cadet-web.de/u/Flynn)\ **Replies:** 0\ **Last updated:** [June 22, 2025, 6:10am UTC](https://forum.cadet-web.de/t/zhang-et-al-2025-an-affinity-complex-titration-isotherm-for-mechanistic-modeling-in-protein-a-chromatography/1245 "2025-06-22T06:10:09Z")
Wendi Zhang, Virginia DiNenna, and Todd Przybycien: An Affinity Complex Titration Isotherm for Mechanistic Modeling in Protein A Chromatography. Biotechnology and Bioengineering (2025). ACT isotherm introduced for mecha… --- ## [CADET-Process v0.11.1 (updated 2025-06-16)](https://forum.cadet-web.de/t/cadet-process-v0-11-1-updated-2025-06-16/1228)
**Author:** [@j.schmoelder](https://forum.cadet-web.de/u/j.schmoelder)\ **Replies:** 1\ **Last updated:** [June 16, 2025, 4:08pm UTC](https://forum.cadet-web.de/t/cadet-process-v0-11-1-updated-2025-06-16/1228 "2025-06-16T16:08:30Z")
CADET-Process v0.11.0 is the culmination of 6 months of dedicated development and collaboration. This release introduces significant new features, critical bug fixes, enhanced test coverage, and improved documentation. W… --- ## [Seeking References on Numerical and Analytical Models in Radial Flow Chromatography](https://forum.cadet-web.de/t/seeking-references-on-numerical-and-analytical-models-in-radial-flow-chromatography/1233)
**Author:** [@Yuvj](https://forum.cadet-web.de/u/Yuvj)\ **Replies:** 0\ **Last updated:** [June 16, 2025, 11:01am UTC](https://forum.cadet-web.de/t/seeking-references-on-numerical-and-analytical-models-in-radial-flow-chromatography/1233 "2025-06-16T11:01:45Z")
Hello everyone, I’ve recently started my master’s thesis project, which focuses on numerical methods for modeling radial flow chromatography. As part of the initial phase, I’m conducting a literature review to assess th… --- ## [Issue plotting comparator in CADET Process v0.11](https://forum.cadet-web.de/t/issue-plotting-comparator-in-cadet-process-v0-11/1230)
**Author:** [@Will\_m32](https://forum.cadet-web.de/u/Will_m32)\ **Replies:** 4\ **Last updated:** [June 13, 2025, 3:53pm UTC](https://forum.cadet-web.de/t/issue-plotting-comparator-in-cadet-process-v0-11/1230 "2025-06-13T15:53:16Z")
Expected behavior. Hi CADET team, I am having trouble running the “comparator.plot\_comparison(simulation\_results)” since updating to Cadet-Process 0.11 from 0.10. This occurs when plotting the comparator directly and wi… --- ## [CADET-Core Version 5.0 Release Announcement (updated 2025-06-13)](https://forum.cadet-web.de/t/cadet-core-version-5-0-release-announcement-updated-2025-06-13/1082)
**Author:** [@lieres](https://forum.cadet-web.de/u/lieres)\ **Replies:** 4\ **Last updated:** [June 13, 2025, 2:50pm UTC](https://forum.cadet-web.de/t/cadet-core-version-5-0-release-announcement-updated-2025-06-13/1082 "2025-06-13T14:50:28Z")
Announcement The CADET team are happy and proud to announce the release of CADET-Core Version 5.0! This version is the result of years of development, featuring a wide range of new features, numerous bug fixes, expanded … --- ## [Cannot import name 'NumpyProxyArray' from 'CADETProcess.dataStructure'](https://forum.cadet-web.de/t/cannot-import-name-numpyproxyarray-from-cadetprocess-datastructure/1229)
**Author:** [@101abhinav](https://forum.cadet-web.de/u/101abhinav)\ **Replies:** 2\ **Last updated:** [June 12, 2025, 6:59am UTC](https://forum.cadet-web.de/t/cannot-import-name-numpyproxyarray-from-cadetprocess-datastructure/1229 "2025-06-12T06:59:31Z")
Expected behavior. I am trying to run my code in which I faced the issue saying cannot import name 'NumpyProxyArray' from 'CADETProcess.dataStructure' (C:\\Users\\modia\\anaconda3\\envs\\cadet-env\\lib\\site-packages\\CADETProc… --- ## [HIC 2016 model in GoSilico and Cadet](https://forum.cadet-web.de/t/hic-2016-model-in-gosilico-and-cadet/1219)
**Author:** [@Shobhith\_V](https://forum.cadet-web.de/u/Shobhith_V)\ **Replies:** 8\ **Last updated:** [June 9, 2025, 8:34pm UTC](https://forum.cadet-web.de/t/hic-2016-model-in-gosilico-and-cadet/1219 "2025-06-09T20:34:00Z")
Hi, I am trying to replicate the HIC 2016 results both in GoSilico and Cadet. In cadet I was using the HIC Water on Hydrophobic surfaces isotherm and was doing this for 1 binding component so that the equations mentioned… --- ## [CSTR causes hanging simulation with low values](https://forum.cadet-web.de/t/cstr-causes-hanging-simulation-with-low-values/1217)
**Author:** [@rosario.cervellere](https://forum.cadet-web.de/u/rosario.cervellere)\ **Replies:** 3\ **Last updated:** [June 5, 2025, 8:11am UTC](https://forum.cadet-web.de/t/cstr-causes-hanging-simulation-with-low-values/1217 "2025-06-05T08:11:43Z")
Expected behavior. Simulation runs with CSTR init\_liquid\_volume \< 1e-4 Actual behavior Simulation hangs with CSTR init\_liquid\_volume \< 1e-4 How to produce bug (including a minimal reproducible example) import pandas as… --- ## [Having Trouble with cadet Path requirement for Cadet-Process import](https://forum.cadet-web.de/t/having-trouble-with-cadet-path-requirement-for-cadet-process-import/1218)
**Author:** [@101abhinav](https://forum.cadet-web.de/u/101abhinav)\ **Replies:** 5\ **Last updated:** [June 3, 2025, 5:58pm UTC](https://forum.cadet-web.de/t/having-trouble-with-cadet-path-requirement-for-cadet-process-import/1218 "2025-06-03T17:58:18Z")
Expected behavior. I am trying to run my test code to see if the cadet has installed properly. But when I run it, it gives the error that cadet cannot be auto detected, please provide the specific path for which I have t… --- ## [Import Error while importing Cadet-process module function](https://forum.cadet-web.de/t/import-error-while-importing-cadet-process-module-function/953)
**Author:** [@Omparv](https://forum.cadet-web.de/u/Omparv)\ **Replies:** 7\ **Last updated:** [May 31, 2025, 2:10pm UTC](https://forum.cadet-web.de/t/import-error-while-importing-cadet-process-module-function/953 "2025-05-31T14:10:00Z")
Hi Everyone, I have tried using cadet-process (being a new user to cadet hence more user friendly), but i am unable to import source and sink post installing cadet-process and am facing import error. Below is the code … [Previous page](https://forum.cadet-web.de/latest.md?page=1) [Next page](https://forum.cadet-web.de/latest.md?page=3)