Breakthrough curve simulation under different feed conc. and flowrates

Hi all,

We have used the cadet equation framework for simulating the breakthrough data in Deulgaonkar et al. (2021). Shi’s paper has a slightly different equation framework than a cadet’s. I have not reproduced Shi’s result with the cadet.

Now, I have tried to reproduce the results of Shi’s paper to answer on a forum at 2 min RT and 0.5, 1 mg/mL feed titer.
The attached file contains a unit conversion excel file, an m file for code, and obtained results in jpg format at 0.5 and 1 mg/mL.
If we use superficial velocity instead of interstitial velocity then we can get same lifting point in the BT curve as in Shi’s paper but I think the broadening of the curve is different due to variations in the equations. I have assumed the 150 kDa molecular weight of the molecule for unit conversion.



BTC.m (2.2 KB)
Unit conversions.xlsx (267.8 KB)