# Gosilico results regeneration in CADET

**URL:** <https://forum.cadet-web.de/t/gosilico-results-regeneration-in-cadet/1164>\
**Category:** Chromatography Modeling\
**Created:** [February 17, 2025, 6:14am UTC](https://forum.cadet-web.de/t/gosilico-results-regeneration-in-cadet/1164 "2025-02-17T06:14:25Z")\
**Posts on this page:** 1\
**Showing post:** 1

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**Author:** ![MrBeast](https://forum.cadet-web.de/user_avatar/forum.cadet-web.de/mrbeast/32/1200_2.png) [@MrBeast](https://forum.cadet-web.de/u/MrBeast)\
**Post date:** [February 17, 2025, 6:14am UTC](https://forum.cadet-web.de/t/gosilico-results-regeneration-in-cadet/1164/1 "2025-02-17T06:14:25Z")

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Hi CADET community,

I hope everyone doing well!  
I am trying to regenerate the Gosilico results in CADET for IEX-SMA process.  
I have trained my model in Gosilico and using same model parameters in Gosilico.  
Following plots showing the comparison between CADET vs Gosilico:

**15 CV Gradient (column.discretization.ncol = 7)**

 ![image](https://forum.cadet-web.de/uploads/default/original/2X/9/98725214ee6b8ca91310540300fd373edc04cd4a.png)

**15 CV Gradient (column.discretization.ncol = 30)**

 ![image](https://forum.cadet-web.de/uploads/default/original/2X/1/17ef0f8d4667f655b84356ffde0dc9ae4aae34d0.png)

**30 CV Gradient (column.discretization.ncol = 7)**

 ![image](https://forum.cadet-web.de/uploads/default/original/2X/3/33a08f5a1f9214c8e3afe2325dc26f767cb9c61d.png)

 ![image](https://forum.cadet-web.de/uploads/default/original/2X/d/d3794d5d5fcb294aadf835bf19db437d1a6e8db2.png)

**Step (column.discretization.ncol = 7)**

 ![image](https://forum.cadet-web.de/uploads/default/original/2X/d/d3ee481ddce0ccd8c3a6894ad438bf82681e2218.png)

**Step (column.discretization.ncol = 30)**

 ![image](https://forum.cadet-web.de/uploads/default/original/2X/d/d34bf047ab629bba05a8d61a984df76c0996daf8.png)

Found interesting results, at column.discretization.ncol 7 match between CADET and Gosilico results more favoured than at discretization ncol 30. Can you please give your suggestions? what should be the actual issue for this mismatch. Ideally, we should use higher discretization, but results are not matching.  
_I have converted keq and kkin into kad and kd by formulas, keq = kad/kd and kkin = 1/kd._

Looking forward to any suggestions.  
Thanks in Advance

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