# Incorporation of loading loading capacity and load conductivity in CEX models

**URL:** <https://forum.cadet-web.de/t/incorporation-of-loading-loading-capacity-and-load-conductivity-in-cex-models/1049>\
**Category:** Chromatography Modeling\
**Created:** [September 10, 2024, 12:00pm UTC](https://forum.cadet-web.de/t/incorporation-of-loading-loading-capacity-and-load-conductivity-in-cex-models/1049 "2024-09-10T12:00:12Z")\
**Posts on this page:** 8\
**Page:** 1

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**Author:** ![Shyama](https://forum.cadet-web.de/letter_avatar_proxy/v4/letter/s/ecccb3/32.png) [@Shyama](https://forum.cadet-web.de/u/Shyama)\
**Post date:** [September 10, 2024, 12:00pm UTC](https://forum.cadet-web.de/t/incorporation-of-loading-loading-capacity-and-load-conductivity-in-cex-models/1049/1 "2024-09-10T12:00:13Z")

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Hi Team,  
I was trying to model for CEX chromatography to incorporate both loading capacity and load conductivity. I have three different loading capacity and load conductivity to evaluate. Can anyone suggest which model incorporates these?  
Any help is appreciated

Regards  
Shyama

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**Author:** ![j.schmoelder](https://forum.cadet-web.de/user_avatar/forum.cadet-web.de/j.schmoelder/32/93_2.png) [@j.schmoelder](https://forum.cadet-web.de/u/j.schmoelder)\
**Post date:** [September 12, 2024, 7:30am UTC](https://forum.cadet-web.de/t/incorporation-of-loading-loading-capacity-and-load-conductivity-in-cex-models/1049/2 "2024-09-12T07:30:22Z")

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Hi Shyama,

could you please be a bit more specific? What do you mean by “incorporate both loading capacity and load conductivity”? What have you tried so far?

Best

Johannes

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**Author:** ![Shyama](https://forum.cadet-web.de/letter_avatar_proxy/v4/letter/s/ecccb3/32.png) [@Shyama](https://forum.cadet-web.de/u/Shyama)\
**Post date:** [September 12, 2024, 11:26am UTC](https://forum.cadet-web.de/t/incorporation-of-loading-loading-capacity-and-load-conductivity-in-cex-models/1049/3 "2024-09-12T11:26:16Z")

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Hi Johannes,

Thanks for your interest. I was trying to develop a CEX chromatography model using SMA isotherm model. In my experimental data, I have taken several loading capacity like 10, 20 and 30, and load conductivity 1, 2 and 3. I want to check the effect of incorporation of different combination of loading capacity and load conductivity in simulation result. I didn’t find any sample code for the same. Please suggest any approach.

Regards  
Shyama

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**Author:** ![j.schmoelder](https://forum.cadet-web.de/user_avatar/forum.cadet-web.de/j.schmoelder/32/93_2.png) [@j.schmoelder](https://forum.cadet-web.de/u/j.schmoelder)\
**Post date:** [September 12, 2024, 3:03pm UTC](https://forum.cadet-web.de/t/incorporation-of-loading-loading-capacity-and-load-conductivity-in-cex-models/1049/4 "2024-09-12T15:03:07Z")

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Please have a look at our [Load-Wash-Elute](https://cadet-process.readthedocs.io/en/v0.9.1/examples/load_wash_elute/index.html) example. It shows how to specify the parameters of the SMA isotherm and how to modulate boundary conditions (which would include the salt concentration / ionic strength as measured by conductivity).

We also have an upcoming workshop, if you’re interested in learning more about modeling with CADET. For more information, see here: [CADET Workshop 2024 Announcement](https://forum.cadet-web.de/t/cadet-workshop-2024-announcement/868)

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**Author:** ![ronald.jaepel](https://forum.cadet-web.de/user_avatar/forum.cadet-web.de/ronald.jaepel/32/986_2.png) [@ronald.jaepel](https://forum.cadet-web.de/u/ronald.jaepel)\
**Post date:** [September 20, 2024, 11:46am UTC](https://forum.cadet-web.de/t/incorporation-of-loading-loading-capacity-and-load-conductivity-in-cex-models/1049/5 "2024-09-20T11:46:07Z")

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Hi Shyama,

just out of curiosity for me: what are the units of the loading capacity and load conductivity numbers?

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**Author:** ![Shyama](https://forum.cadet-web.de/letter_avatar_proxy/v4/letter/s/ecccb3/32.png) [@Shyama](https://forum.cadet-web.de/u/Shyama)\
**Post date:** [September 26, 2024, 12:40pm UTC](https://forum.cadet-web.de/t/incorporation-of-loading-loading-capacity-and-load-conductivity-in-cex-models/1049/6 "2024-09-26T12:40:02Z")

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Hi Ronald,

Thanks for your interest.  
The unit of loading capacity is mg/mL and load conductivity is mS/cm.

Regards

Shyama

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**Author:** ![Shyama](https://forum.cadet-web.de/letter_avatar_proxy/v4/letter/s/ecccb3/32.png) [@Shyama](https://forum.cadet-web.de/u/Shyama)\
**Post date:** [November 28, 2024, 6:11am UTC](https://forum.cadet-web.de/t/incorporation-of-loading-loading-capacity-and-load-conductivity-in-cex-models/1049/7 "2024-11-28T06:11:22Z")

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Hi Ronald,

Please help me, to incorporate loading capacity and and load conductivity. The unit of loading capacity is mg/mL and load conductivity is mS/cm.

Regards

Shyama

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**Author:** ![j.schmoelder](https://forum.cadet-web.de/user_avatar/forum.cadet-web.de/j.schmoelder/32/93_2.png) [@j.schmoelder](https://forum.cadet-web.de/u/j.schmoelder)\
**Post date:** [November 28, 2024, 8:22am UTC](https://forum.cadet-web.de/t/incorporation-of-loading-loading-capacity-and-load-conductivity-in-cex-models/1049/8 "2024-11-28T08:22:49Z")

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You need to perform a conductivity sensor calibration to infer the salt concentration from the conductivity signal.
