CADET-Process PCC Cycling Problem

CADET Troubleshooting
1

Hey,

I have bit working on a periodic counter current chromatography code with 3 columns and have been having a problem when the with the cycling of the process events. Going from the last event (step 6) to the first event (step 1), no protein is eluting out of the third column.

p1 correct
p1 correct1410×897 78.3 KB

Do yall know what is happening?

Code: CADET-Process script for 3 column PCC as depicted in: https://doi.org/10.1002/bit.27689 · GitHub
Cadet Process fork I am using: GitHub - angelamoser1/CADET-Process at add_GRM_surface_diffusion_dependence
PCC set up: 10.1002/bit.27689

A bit of context about the code:
Waste wash outlet is the outlet for when the columns are washed and the waste outlet is the outlet for when the columns are being loaded.
t_C is split up into an eluting and equilibration, since we want the column that is being eluted to be brought back up to a pH of 7 once elution ends.

2

Hi Daniel,

which CADET-Core version are you using?

The Code is crashing with
CADETProcess.CADETProcessError.CADETProcessError: CADET Error: Simulation failed with b'IO ERROR: Field "COL_RADIUS" does not exist in group /input/model/unit_003/adsorption\r\n'

edit: I figured it out myself, it works with the current master version of CADET-Core.

3

Found the bug. Fix will be out in a few days.

1 Like
4

Fix has been merged into the dev branch. To include it in your analyses the easiest approach would be to rebase your local branch onto the current dev branch. LMK how that works out for you.